Children\u27s beliefs about hierarchical structures and relationships.

Children are surrounded by social structures such as families, schools, and workplaces which are often arranged hierarchically with some people holding more power than others. This dissertation explores how children think about hierarchical relationships and more complex hierarchical structures. In Chapter 2, children were asked to evaluate the traits of people who hold hierarchically dominant and subordinate social roles. With age, 4- to 6-year-olds increasingly inferred that dominant individuals have social power and they deferred to their instructions (Chapter 2, Study 1). Furthermore, 5- and 6-year-olds attributed knowledgeability to individuals with dominant social roles but overall children did not prefer to ask those individuals for information (Chapter 2, Study 2). Chapter 3 extended these studies by presenting children with larger social structures depicting gender and racial inequality and asking children to recognize inequality (Study 1), rectify inequality (Study 2) and create social hierarchies (Study 3). Regardless of age, participants judged hierarchies with more than one woman or Black man in a position of power as fair. However, hierarchies with only one minoritized individual were judged as neutral in gender hierarchies or unfair in racial hierarchies (Chapter 3, Study 1). Children were also asked to rectify inequality by promoting individuals to positions of power in unequal control (arbitrary non-social color groups), gender, and racial hierarchies. Children selected to promote majoritized individuals to positions of power when they were arbitrary groups and children’s gender influenced their responses to gender inequality where girls promoted more women to positions of power than boys (Chapter 3, Study 2). Lastly, children created a social hierarchy without the influence of representations of inequality. In-group gender favoritism drove children’s selections where girls selected more women than men for every tier of the hierarchy but boys were only influenced by gender when selecting someone for the top of the hierarchy. When making racial hierarchies, children selected both White men and Black men equally to be in positions of power (Chapter 3, Study 3). These studies suggest that children can infer power from simple hierarchical structures and that they are motivated to rectify inequalities in more complex social structures

Choosing Sides: Children’s Expectations of Consequences of Loyalty Towards Authority

Previous research has found that children recognize social group membership and status early in development (Aboud, 2003; Gulgoz & Gelman, 2017). However, children increasingly value loyalty towards authority figures with age, although they prefer members of their own social groups (Norris & Noles, 2022). In this study, we are interested in whether children expect there to be positive consequences associated with loyalty towards authority figures over a subordinate, as well as negative consequences associated with loyalty towards subordinates over authority figures. We presented children ages 6-8, as well as adults, with a situation in which a worker was loyal to either the boss (authority figure) or another worker (subordinate). We then asked two questions: whether the boss was nice to the (dis)loyal worker (Positive Consequence) or mean to them (Negative Consequence). Both children and adults significantly chose the worker to receive a negative consequence when the worker was loyal to the subordinate as well as to receive a positive consequence when the worker was loyal to the boss. These results suggest that at a young age, children recognize that risks are associated with loyalty towards authority figures over in-group members. Future studies should further explore how loyalty influences the way children interact in relationships with friends, parents, and teachers

Stay and Play with Mickey Mouse: Familiar Characters Increase Children’s Exploratory Play

When children are introduced to a novel toy, they explore to discover how the toy works, but do not always discover all of the functions (Bonawitz et al., 2011). Research has shown that children prefer objects with a familiar character on them (Danovitch & Mills, 2014). This study investigates whether the presence of a familiar character’s image on a novel toy encourages exploratory play. Four- and 5-year-olds (n = 40) were presented with a novel toy, containing 5 different functions, that either displayed an image of their favorite familiar character or an image of that character’s color scheme. Children were given up to 5 minutes to play with the toy. Children’s play was coded for the number of functions they discovered and how long they played with the toy. Results showed no significant difference between conditions for number of functions discovered. However, children who were given a toy with their favorite character’s image on it spent significantly more time exploring the toy than children who had a toy with the character’s color scheme on it. These findings suggest that seeing a familiar character on an object promotes children’s exploration of that object.https://ir.library.louisville.edu/uars/1010/thumbnail.jp

Geographic Variation of Strontium and Hydrogen Isotopes in Avian Tissue: Implications for Tracking Migration and Dispersal

Background: Isotopes can provide unique solutions to fundamental problems related to the ecology and evolution of migration and dispersal because prior movements of individuals can theoretically be tracked from tissues collected from a single capture. However, there is still remarkably little information available about how and why isotopes vary in wild animal tissues, especially over large spatial scales. Methodology/Principal Findings: Here, we describe variation in both stable-hydrogen (dDF) and strontium ( 87Sr/86SrF) isotopic compositions in the feathers of a migratory songbird, the Tree Swallow (Tachycineta bicolor), across 18 sampling sites in North America and then examine potential mechanisms driving this variation. We found that dDF was correlated with latitude of the sampling site, whereas 87Sr/86SrF was correlated with longitude. dDF was related to dD of meteoric waters where molting occurred and 87Sr/86SrF was influenced primarily by the geology in the area where feathers were grown. Using simulation models, we then assessed the utility of combining both markers to estimate the origin of individuals. Using 13 geographic regions, we found that the number of individuals correctly assigned to their site of origin increased from less than 40 % using either dD or 87Sr/86Sr alone to 74 % using both isotopes. Conclusions/Significance: Our results suggest that these isotopes have the potential to provide predictable an

A population of gamma-ray emitting globular clusters seen with the Fermi Large Area Telescope

Globular clusters with their large populations of millisecond pulsars (MSPs) are believed to be potential emitters of high-energy gamma-ray emission. Our goal is to constrain the millisecond pulsar populations in globular clusters from analysis of gamma-ray observations. We use 546 days of continuous sky-survey observations obtained with the Large Area Telescope aboard the Fermi Gamma-ray Space Telescope to study the gamma-ray emission towards 13 globular clusters. Steady point-like high-energy gamma-ray emission has been significantly detected towards 8 globular clusters. Five of them (47 Tucanae, Omega Cen, NGC 6388, Terzan 5, and M 28) show hard spectral power indices $(0.7 < \Gamma <1.4)$ and clear evidence for an exponential cut-off in the range 1.0-2.6 GeV, which is the characteristic signature of magnetospheric emission from MSPs. Three of them (M 62, NGC 6440 and NGC 6652) also show hard spectral indices $(1.0 < \Gamma < 1.7)$, however the presence of an exponential cut-off can not be unambiguously established. Three of them (Omega Cen, NGC 6388, NGC 6652) have no known radio or X-ray MSPs yet still exhibit MSP spectral properties. From the observed gamma-ray luminosities, we estimate the total number of MSPs that is expected to be present in these globular clusters. We show that our estimates of the MSP population correlate with the stellar encounter rate and we estimate 2600-4700 MSPs in Galactic globular clusters, commensurate with previous estimates. The observation of high-energy gamma-ray emission from a globular cluster thus provides a reliable independent method to assess their millisecond pulsar populations that can be used to make constraints on the original neutron star X-ray binary population, essential for understanding the importance of binary systems in slowing the inevitable core collapse of globular clusters.Comment: Accepted for publication in A&A. Corresponding authors: J. Kn\"odlseder, N. Webb, B. Pancraz

Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes

Members of ENDIA Study Group: Peter Baghurst, Simon Barry, Jodie Dodd, Maria Makrides for the University of Adelaide.BACKGROUND The incidence of type 1 diabetes has increased worldwide, particularly in younger children and those with lower genetic susceptibility. These observations suggest factors in the modern environment promote pancreatic islet autoimmunity and destruction of insulin-producing beta cells. The Environmental Determinants of Islet Autoimmunity (ENDIA) Study is investigating candidate environmental exposures and gene-environment interactions that may contribute to the development of islet autoimmunity and type 1 diabetes. METHODS/DESIGN ENDIA is the only prospective pregnancy/birth cohort study in the Southern Hemisphere investigating the determinants of type 1 diabetes in at-risk children. The study will recruit 1,400 unborn infants or infants less than six months of age with a first-degree relative (i.e. mother, father or sibling) with type 1 diabetes, across five Australian states. Pregnant mothers/infants will be followed prospectively from early pregnancy through childhood to investigate relationships between genotype, the development of islet autoimmunity (and subsequently type 1 diabetes), and prenatal and postnatal environmental factors. ENDIA will evaluate the microbiome, nutrition, bodyweight/composition, metabolome-lipidome, insulin resistance, innate and adaptive immune function and viral infections. A systems biology approach will be used to integrate these data. Investigation will be by 3-monthly assessments of the mother during pregnancy, then 3-monthly assessments of the child until 24 months of age and 6-monthly thereafter. The primary outcome measure is persistent islet autoimmunity, defined as the presence of autoantibodies to one or more islet autoantigens on consecutive tests. DISCUSSION Defining gene-environment interactions that initiate and/or promote destruction of the insulin-producing beta cells in early life will inform approaches to primary prevention of type 1 diabetes. The strength of ENDIA is the prospective, comprehensive and frequent systems-wide profiling from early pregnancy through to early childhood, to capture dynamic environmental exposures that may shape the development of islet autoimmunity. TRIAL REGISTRATION Australia New Zealand Clinical Trials Registry ACTRN12613000794707.Megan AS Penno, Jennifer J Couper, Maria E Craig, Peter G Colman, William D Rawlinson, Andrew M Cotterill, Timothy W Jones, Leonard C Harrison and ENDIA Study Grou

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely

‘An ounce of loyalty’: Children’s expectations about loyalty and preference for in-group members and authority figures

The current study investigates children’s understanding of the social dynamics of complex groups. We asked children to use relative differences in intragroup status to predict the behaviors of individuals. Specifically, who do children (ages 3 to 10, n = 120) and adults (n = 34) believe a subordinate “worker” would be loyal to (another worker or to their “boss”), and whom the worker would prefer to socialize with? Young children predicted that workers would be loyal to other workers, but as age increased so did children’s tendency to predict that workers would be loyal to bosses. Regardless of age, children and adults believed that workers would prefer to spend time with other workers. These results have important implications for how children understand and navigate nuanced power differentials within a group